Shanghai Bailun Biotechnology Co., Ltd.
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WAVE reactor
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WAVE reactor
- product description
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- Commodity name: WAVE reactor
Bailun Biotech provides innovative WAVE bioreactor solutions for the biopharmaceutical industry, and its core technologies cover the entire process from pilot to cGMP production. Bailun WAVE bioreactor uses a unique rocking mixing design to achieve wave motion of the culture medium without mechanical stirring, significantly improving the oxygen mass transfer coefficient (kLa value of 8.8-28 h⁻¹), while avoiding high shear damage of traditional stirring paddles. The system supports multiple application scenarios such as viral vaccines, CHO cell monoclonal antibodies, T cell therapy, and stem cell culture, and is suitable for conventional batches, feed batches, and perfusion processes. In particular, it can achieve a breakthrough performance of CHO cell density of up to 1.46×10⁸ cells/mL in perfusion culture. Bailun WAVE bioreactor is equipped with an intelligent control system, integrating high-precision fiber optic pH/DO sensors, multi-channel gas mass flow meters, and touch screen human-machine interfaces, which can perform PD feedback closed-loop control of parameters such as temperature (±0.1℃ accuracy), dissolved oxygen (0.1% resolution), and pH. Its modular design supports the rapid replacement of 10-50L disposable cell bags, and combined with the gamma-ray pre-sterilized medical-grade polyethylene culture bag system, it can be installed and used immediately, significantly reducing the risk of cross-contamination and complying with FDA 21 CFR Part11 and GMP airtightness requirements. For emerging fields such as regenerative medicine, the full set of sterile consumables (including cell bags, tubing, and filter membranes) developed by Bailun uses anti-dissolution validation materials to ensure process robustness. The matching weighing linkage perfusion system and data traceability software can shorten the process development cycle by 30%, and accelerate the drug application process through three-level authority management and audit tracking functions. The platform has been successfully applied to the continuous production processes of many domestic biopharmaceutical companies, helping to reduce the production cost of monoclonal antibody drugs by 40%.
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Shanghai Bailun Biotechnology Co., Ltd.
Liu Xiang Road 6848， Hua Ting Town, Jiading District, Shanghai
E-mail：15821268711@163.com