Shanghai Bailun Biotechnology Co., Ltd.
BAILUN Laboratory
Research on bacterial strains and processes
Bailun Laboratory takes synthetic biology and system metabolic engineering as its technical cornerstone, and builds a full life cycle solution from gene design to industrial implementation around the directional transformation and large-scale production needs of industrial microorganisms, providing innovative and practical technical support for biomanufacturing, pharmaceutical research and development, agricultural technology and green chemical industry. By integrating CRISPR gene editing, adaptive evolution strategy and high-throughput automated screening platform, we focus on the precise regulation of microbial metabolic network, break through the metabolic efficiency limit of natural strains, and reconstruct the biosynthetic pathway of non-natural products; combined with multi-omics analysis and machine learning algorithms, we systematically optimize the robustness and environmental adaptability of strains to ensure their stable expression in complex industrial environments. In terms of process development, relying on intelligent fermentation kinetic models and real-time metabolic flow monitoring technology, we have established a step-by-step amplification system from laboratory shake flasks to large-scale fermentation tanks. By dynamically regulating dissolved oxygen, feeding strategies and product feedback inhibition mechanisms, we significantly improve product concentration and purity. At the same time, we strictly follow international quality management specifications to achieve seamless connection between process parameters and production standards.
In response to the needs of downstream industrialization, we have innovatively developed efficient separation and purification technologies, combined with continuous flow chromatography processes and green crystallization solutions, to overcome the problem of product recovery rate and energy consumption balance, and provide sustainable process paths for the production of bio-based materials, high value-added natural products and pharmaceutical intermediates. At the service level, we provide full-chain support covering strain library construction, process package development, and technology transfer training, and deeply participate in the full-process collaboration of customers from laboratory research to commercial production to ensure that technical solutions are quickly adapted to diversified scenarios. At present, technical achievements have been widely used in the fields of biodegradable plastic monomer synthesis, amino acid fermentation system optimization, and new antibiotic development, helping companies reduce their dependence on fossil raw materials and accelerate green manufacturing transformation. In the future, we will continue to explore the deep integration of microorganisms, artificial intelligence, and low-carbon processes, and drive the infinite possibilities of the bioeconomy with underlying technological innovations - making each strain of engineered bacteria a green engine for reshaping the future of industry.
Shanghai Bailun Biotechnology Co., Ltd.
Liu Xiang Road 6848， Hua Ting Town, Jiading District, Shanghai
